The three keywords for our research are cancer, immunity, and iron metabolism. We previously revealed 1) an ubiquitin network involving the regulation of mammalian iron metabolism, 2) regulatory mechanisms of the Hippo intracellular pathway, and 3) a regulatory mechanism of host anti-cancer immunity by the tumor-intrinsic signaling pathway. The goal of our research is to understand cell-cell communication mechanisms regulating tissue homeostasis, and to provide scientific basis for drug discovery.